Acetate → 5-(1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrazine-2-carbonitrile

HRID 312405Notes

Reaction equation

HRID 312405 reaction equation
[CH3:10][C:11]([CH3:12])([O-:13])[CH3:14].[CH3:16][O:17][c:18]1[cH:19][cH:20][c:21]([CH2:22][n:23]2[cH:24][n:25][c:26]3[cH:27][n:28][c:29]([Br:32])[cH:30][c:31]23)[cH:33][cH:34]1.[CH3:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1.[NH2:1][c:2]1[n:3][cH:4][c:5]([C:8]#[N:9])[n:6][cH:7]1.[Na+:15].[O-:48][C:49]([CH3:50])=[O:51].[O-:52][C:53]([CH3:54])=[O:55].[O:35]=[CH:36][N:37]([CH3:38])[CH3:39].[Pd+2:47]>>[NH:1]([c:2]1[n:3][cH:4][c:5]([C:8]#[N:9])[n:6][cH:7]1)[c:29]1[n:28][cH:27][c:26]2[n:25][cH:24][n:23]([CH2:22][c:21]3[cH:20][cH:19][c:18]([O:17][CH3:16])[cH:34][cH:33]3)[c:31]2[cH:30]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 923Sodium ionHCID 1140TolueneHCID 6228DimethylformamideHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 45749132-Methylpropan-2-olateHCID 139252945-Aminopyrazine-2-carbonitrileHCID 569264661-(4-methoxybenzyl)-6-bromo-1H-imidazo[4,5-c]pyridine

Product 1

HCID 442043575-(1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrazine-2-carbonitrile

Sources & evidence

ORD record
ord-fb7f26d54d3f4569b6ef0d93a2d1ce52
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…