Water → 4-Chloro-6-(1-methylpyrazol-4-yl)thieno[3,2-d]pyrimidine

HRID 312450Notes

Reaction equation

HRID 312450 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[n:5][cH:6][n:7][c:8]([Cl:11])[c:9]2[s:10]1.[CH3:12][n:13]1[n:14][cH:15][c:16]([B:18]2[O:19][C:20]([CH3:21])([CH3:22])[C:23]([CH3:24])([CH3:25])[O:26]2)[cH:17]1.[O:27]=[CH:28][N:29]([CH3:30])[CH3:31].[O:34]=[C:35]([CH:36]=[CH:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[CH:44]=[CH:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1.[O:52]=[C:53]([CH:54]=[CH:55][c:56]1[cH:57][cH:58][cH:59][cH:60][cH:61]1)[CH:62]=[CH:63][c:64]1[cH:65][cH:66][cH:67][cH:68][cH:69]1.[O:70]=[C:71]([CH:72]=[CH:73][c:74]1[cH:75][cH:76][cH:77][cH:78][cH:79]1)[CH:80]=[CH:81][c:82]1[cH:83][cH:84][cH:85][cH:86][cH:87]1.[OH2:88].[Pd:32].[Pd:33]>>[c:2]1(-[c:16]2[cH:15][n:14][n:13]([CH3:12])[cH:17]2)[cH:3][c:4]2[n:5][cH:6][n:7][c:8]([Cl:11])[c:9]2[s:10]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 23938Palladium2×HCID 95417Dibenzylidene acetone3×HCID 27739871-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 183827966-Bromo-4-chlorothieno(3,2-d)pyrimidine

Product 1

HCID 860949964-Chloro-6-(1-methylpyrazol-4-yl)thieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-d25c8765651b4694bf39c4fb49ef20fa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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