Acetic Acid → 4-(4-Aminofuro[3,2-c]pyridin-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile

HRID 312587Notes

Reaction equation

HRID 312587 reaction equation
[C:1](#[N:2])[C:3]1=[C:4]([CH3:30])[NH:5][C:6]([CH3:29])=[C:7]([C:27]#[N:28])[CH:8]1[c:9]1[cH:10][c:11]2[c:12]([NH:18][C:19](=[O:20])[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[n:13][cH:14][cH:15][c:16]2[o:17]1.[CH3:38][C:39](=[O:40])[OH:41].[ClH:31].[Na+:32].[Na+:33].[O-:34][C:35](=[O:36])[O-:37]>>[C:1](#[N:2])[C:3]1=[C:4]([CH3:30])[NH:5][C:6]([CH3:29])=[C:7]([C:27]#[N:28])[CH:8]1[c:9]1[cH:10][c:11]2[c:12]([NH2:18])[n:13][cH:14][cH:15][c:16]2[o:17]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 52938807N-[2-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)furo[3,2-c]pyridin-4-yl]benzamide

Product 1

HCID 529205034-(4-Aminofuro[3,2-c]pyridin-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile

Sources & evidence

ORD record
ord-05aa450a27cc4fd195a04b4b75e05690
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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