Dimethylformamide → 6-(2,2-Dimethoxyethoxy)-1-oxo-1,2,3,4-tetrahydroisoquinoline

HRID 313015Notes

Reaction equation

HRID 313015 reaction equation
[C:20](=[O:21])([O-:22])[O-:23].[CH3:13][O:14][CH:15]([CH2:16][Br:17])[O:18][CH3:19].[Cs+:24].[Cs+:25].[O:26]=[CH:27][N:28]([CH3:29])[CH3:30].[OH:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[C:8](=[O:12])[NH:7][CH2:6][CH2:5]2>>[O:1]([c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[C:8](=[O:12])[NH:7][CH2:6][CH2:5]2)[CH2:16][CH:15]([O:14][CH3:13])[O:18][CH3:19]

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 816722-Bromo-1,1-dimethoxyethaneHCID 104967Cesium cation2×HCID 159083146-Hydroxy-1,2,3,4-tetrahydroisoquinolin-1-one

Product 1

HCID 189638836-(2,2-Dimethoxyethoxy)-1-oxo-1,2,3,4-tetrahydroisoquinoline

Sources & evidence

ORD record
ord-1fe47354a34d4f48a4e28cb6a6b72c5e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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