反应详情

1.5 g of levofloxacin crude and 36 mg of ascorbic acid were put in suspension in 9.5 ml of n-BuOH under inert atmosphere. The mixture was heated to reflux temperature and a hot filtration was performed. The solution was then evaporated to dryness and n-BuOH (10 ml) was added. The mixture was heated to reflux until complete dissolution and then cooled to RT over a period of 1.5 hour. The precipitate was filtrated under vacuum, washed with n-BuOH (4 ml) and dried at 60° C. in a vacuum oven to give 840 mg (56%) of purified levofloxacin hemihydrate.

1. temperatureThe mixture was heated
2. temperatureto reflux temperature
3. filtrationa hot filtration
4. customThe solution was then evaporated to dryness and n-BuOH (10 ml)
5. additionwas added
6. temperatureThe mixture was heated
7. temperatureto reflux until complete dissolution
8. filtrationThe precipitate was filtrated under vacuum
9. washwashed with n-BuOH (4 ml)
10. customdried at 60° C. in a vacuum oven