Ethanol → Ethyl 3-(cyclopentylamino)-2-fluoro-2-methylpropanoate

HRID 313750Notes

Reaction equation

HRID 313750 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]([CH2:9][C:10]([C:11](=[O:12])[O:13][CH2:14][CH3:15])([CH3:16])[F:17])[CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1.[CH3:30][CH2:31][OH:32].[F:23][C:24]([F:25])([F:26])[C:27]([OH:28])=[O:29].[OH-:33].[OH-:34].[Pd+2:35]>>[NH:8]([CH2:9][C:10]([C:11](=[O:12])[O:13][CH2:14][CH3:15])([CH3:16])[F:17])[CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1

Participants

6

Reactant 5

HCID 702EthanolHCID 961Hydroxide2×HCID 6422Trifluoroacetic acidHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 57955642Ethyl 3-(benzyl(cyclopentyl)amino)-2-fluoro-2-methylpropanoate

Product 1

HCID 57955537Ethyl 3-(cyclopentylamino)-2-fluoro-2-methylpropanoate

Sources & evidence

ORD record
ord-b9b939cc48ee48baafd0c16f16485bc0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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