4-(4-Bromophenyl)-1,3-thiazol-2-amine hydrobromide → 4'-(2-Amino-4-thiazolyl)-6-methyl-N-[3-(4-morpholinyl)phenyl][1,1'-biphenyl]-3-carboxamide

HRID 31431Notes

Reaction equation

HRID 31431 reaction equation
Br.Br[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([NH2:14])[S:12][CH:13]=2)=[CH:5][CH:4]=1.[CH3:15][C:16]1[CH:36]=[CH:35][C:19]([C:20]([NH:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)[CH:24]=2)=[O:21])=[CH:18][C:17]=1B1OC(C)(C)C(C)(C)O1>>[NH2:14][C:11]1[S:12][CH:13]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:17]3[C:16]([CH3:15])=[CH:36][CH:35]=[C:19]([C:20]([NH:22][C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([N:29]5[CH2:34][CH2:33][O:32][CH2:31][CH2:30]5)[CH:24]=4)=[O:21])[CH:18]=3)=[CH:4][CH:5]=2)[N:10]=1

Participants

3

Reactant 2

HCID 27878804-(4-Bromophenyl)-1,3-thiazol-2-amine hydrobromideHCID 597915214-methyl-N-[3-(4-morpholinyl)phenyl]-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide2×

Product 1

HCID 99563634'-(2-Amino-4-thiazolyl)-6-methyl-N-[3-(4-morpholinyl)phenyl][1,1'-biphenyl]-3-carboxamide

Procedure

Example 1 was prepared using 4-(4-bromophenyl)-2-thiazolamine monohydrobromide and 4-methyl-N-[3-(4-morpholinyl)phenyl]-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide (Intermediate 5).

Workup

  1. customExample 1 was prepared

Sources & evidence

ORD record
ord-e7d90018ed3d40209c184f4d2fd498a8
Source dataset
uspto-grants-2008_09
Patent number
US07425555B2

Reaction notes

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