2-(4-bromophenyl)-1H-imidazole → 4'-(1H-Imidazol-2-yl)-6-methyl-N-[3-(4-morpholinyl)phenyl][1,1'-biphenyl]-3-carboxamide

HRID 31434Notes

Reaction equation

HRID 31434 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][CH:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[CH3:13][C:14]1[CH:34]=[CH:33][C:17]([C:18]([NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[CH:22]=2)=[O:19])=[CH:16][C:15]=1B1OC(C)(C)C(C)(C)O1>>[NH:12]1[CH:11]=[CH:10][N:9]=[C:8]1[C:5]1[CH:6]=[CH:7][C:2]([C:15]2[C:14]([CH3:13])=[CH:34][CH:33]=[C:17]([C:18]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)[CH:22]=3)=[O:19])[CH:16]=2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 116942652-(4-bromophenyl)-1H-imidazoleHCID 597915214-methyl-N-[3-(4-morpholinyl)phenyl]-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide2×

Product 1

HCID 104782974'-(1H-Imidazol-2-yl)-6-methyl-N-[3-(4-morpholinyl)phenyl][1,1'-biphenyl]-3-carboxamide

Procedure

Example 4 was prepared using 2-(4-bromophenyl)-1H-imidazole and 4-methyl-N-[3-(4-morpholinyl)phenyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (Intermediate 5).

Workup

  1. customExample 4 was prepared

Sources & evidence

ORD record
ord-40a8600da11f46238dbf229ba6b2f4b8
Source dataset
uspto-grants-2008_09
Patent number
US07425555B2

Reaction notes

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