Bromide ion → Tert-butyl 5-[2-acetamido-3-(3-fluoro-5-propylphenyl)-1-hydroxypropyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylate
Reaction equation
[Br-:1].[C:6]([CH3:7])([CH3:8])([CH3:9])[O:10][C:11](=[O:12])[N:13]1[CH:14]([CH3:41])[CH:15]([O:35][CH2:36][C:37]([CH3:38])([CH3:39])[CH3:40])[O:16][CH2:17][CH:18]1[CH:19]([CH:20]([CH2:21][c:22]1[cH:23][c:24]([Br:29])[cH:25][c:26]([F:28])[cH:27]1)[NH:30][C:31]([CH3:32])=[O:33])[OH:34].[CH2:2]([CH2:3][CH3:4])[Zn+:5].[Cl:47][Pd:48][Cl:49].[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[CH2:2]([CH2:3][CH3:4])[c:24]1[cH:23][c:22]([CH2:21][CH:20]([CH:19]([CH:18]2[N:13]([C:11]([O:10][C:6]([CH3:7])([CH3:8])[CH3:9])=[O:12])[CH:14]([CH3:41])[CH:15]([O:35][CH2:36][C:37]([CH3:38])([CH3:39])[CH3:40])[O:16][CH2:17]2)[OH:34])[NH:30][C:31]([CH3:32])=[O:33])[cH:27][c:26]([F:28])[cH:25]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-861c6e2d123341de8fcfbb3f1fc6c79c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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