Dimethylformamide → 5-(2'-chloro-5-methyl-2-(1-(pyridin-2-yl)cyclopropyl carbamoyl)biphenyl-4-yl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

HRID 314721Notes

Reaction equation

HRID 314721 reaction equation
[Cl:1][c:2]1[c:3](-[c:8]2[c:9]([C:35](=[O:36])[OH:37])[cH:10][c:11](-[c:15]3[cH:16][cH:17][c:18]4[c:19]([c:20]([C:30]([NH:31][CH3:32])=[O:33])[c:21](-[c:23]5[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]5)[o:22]4)[cH:34]3)[c:12]([CH3:14])[cH:13]2)[cH:4][cH:5][cH:6][cH:7]1.[O:72]=[CH:73][N:74]([CH3:75])[CH3:76].[P-:48]([F:49])([F:50])([F:51])([F:52])([F:53])[F:54].[n:38]1[c:39]([C:44]2([NH2:47])[CH2:45][CH2:46]2)[cH:40][cH:41][cH:42][cH:43]1.[n:55]1([O:56][C:57]([N:58]([CH3:59])[CH3:60])=[N+:61]([CH3:62])[CH3:63])[c:64]2[n:65][cH:66][cH:67][cH:68][c:69]2[n:70][n:71]1>>[Cl:1][c:2]1[c:3](-[c:8]2[c:9]([C:35](=[O:36])[NH:47][C:44]3([c:39]4[n:38][cH:43][cH:42][cH:41][cH:40]4)[CH2:45][CH2:46]3)[cH:10][c:11](-[c:15]3[cH:16][cH:17][c:18]4[c:19]([c:20]([C:30]([NH:31][CH3:32])=[O:33])[c:21](-[c:23]5[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]5)[o:22]4)[cH:34]3)[c:12]([CH3:14])[cH:13]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 111054091-(Pyridin-2-yl)cyclopropanamineHCID 592757392'-Chloro-4-(2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-5-methylbiphenyl-2-carboxylic acid

Product 1

HCID 592754395-(2'-chloro-5-methyl-2-(1-(pyridin-2-yl)cyclopropyl carbamoyl)biphenyl-4-yl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Sources & evidence

ORD record
ord-750544c8017b424b9734603ebb4d21d1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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