反应详情

A solution of 0.6 g (4.2 mmol) of benzoylchloride in 10 ml of methylene chloride is added dropwise to a solution of 1 g (4 mmol) of 3-cyano-N-(4-amino-benzyl)-benzamide and 0.6 g (6 mmol) of triethylamine in 30 ml of methylene chloride at ambient temperature. After 8 hours at ambient temperature the product which has crystallised out is dissolved in methylene chloride and methanol. After extraction with water the combined organic extracts are dried and evaporated down.

1. customAfter 8 hours at ambient temperature the product which has crystallised out
2. dissolutionis dissolved in methylene chloride
3. extractionAfter extraction with water the combined organic extracts
4. customare dried
5. customevaporated down