HRID31533

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

结构：CC(C)(C)OC(=O)Nc1cc(C(=O)NC2CCCCC2OCc2ccccc2)n(CC(=O)NC2CCCCC2OCc2ccccc2)n1

HCID68870936

未命名化合物

PRODUCTS

生成物

结构：Nc1cc(C(=O)NC2CCCCC2OCc2ccccc2)n(CC(=O)NC2CCCCC2OCc2ccccc2)n1

HCID73233771

未命名化合物

收率 96.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of {5-(2-Benzyloxy-cyclohexylcarbamoyl)-1-[(2-benzyloxy-cyclohexylcarbamoyl)-methyl]-1H-pyrazol-3-yl}-carbamic acid tert-butyl ester (0.5 gm) in 5 ml of dichloromethane was added 1 ml of 4N hydrochloric acid/dioxane. After stirring for 6 hours the mixture was evaporated to dryness to obtain 0.41 gm of title product as the hydrochloride salt. ESI M+1=560.

WORKUP

后处理

customwas evaporated to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f0a3b0dacf6a4effb574bf14fa04816e
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07425640B2
来源说明: uspto-grants-2008_09

反应 SMILES

C(OC(=O)[NH:7][C:8]1[CH:12]=[C:11]([C:13](=[O:29])[NH:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH:16]2[O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:10]([CH2:30][C:31](=[O:47])[NH:32][CH:33]2[CH2:38][CH2:37][CH2:36][CH2:35][CH:34]2[O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[N:9]=1)(C)(C)C.Cl.O1CCOCC1>ClCCl>[CH2:22]([O:21][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH:15]1[NH:14][C:13]([C:11]1[N:10]([CH2:30][C:31](=[O:47])[NH:32][CH:33]2[CH2:38][CH2:37][CH2:36][CH2:35][CH:34]2[O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[N:9]=[C:8]([NH2:7])[CH:12]=1)=[O:29])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1