1,4-Dioxane hydrochloride → 5-Amino-2-[(2-benzyloxy-cyclohexylcarbamoyl)-methyl]-2H-pyrazole-3-carboxylic acid (2-benzyloxy-cyclohexyl)-amide

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Reaction Steps

To a solution of {5-(2-Benzyloxy-cyclohexylcarbamoyl)-1-[(2-benzyloxy-cyclohexylcarbamoyl)-methyl]-1H-pyrazol-3-yl}-carbamic acid tert-butyl ester (0.5 gm) in 5 ml of dichloromethane was added 1 ml of 4N hydrochloric acid/dioxane. After stirring for 6 hours the mixture was evaporated to dryness to obtain 0.41 gm of title product as the hydrochloride salt. ESI M+1=560.

Provenance & Evidence