Hydroxide → Avadomide

HRID 316129Notes

Reaction equation

HRID 316129 reaction equation
[CH3:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][c:8]([N+:21]([O-:22])=[O:23])[c:9]2[c:10](=[O:20])[n:11]1[CH:12]1[C:13](=[O:19])[NH:14][C:15](=[O:18])[CH2:16][CH2:17]1.[O:24]=[CH:25][N:26]([CH3:27])[CH3:28].[OH-:29].[OH-:30].[Pd+2:31]>>[CH3:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][c:8]([NH2:21])[c:9]2[c:10](=[O:20])[n:11]1[CH:12]1[C:13](=[O:19])[NH:14][C:15](=[O:18])[CH2:16][CH2:17]1

Participants

5

Reactant 4

HCID 961Hydroxide2×HCID 6228DimethylformamideHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 666429823-(2-methyl-5-nitro-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione

Product 1

HCID 24967599Avadomide

Sources & evidence

ORD record
ord-590b2ba800c14fa3a4290546ba5a1760
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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