Dichloromethane → Piperidin-4-yl-(2-trifluoromethylphenyl)amine

HRID 316381Notes

Reaction equation

HRID 316381 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[c:16]([C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:25][CH2:26][Cl:27].[OH:28][C:29]([C:30]([F:31])([F:32])[F:33])=[O:34]>>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[c:16]([C:21]([F:22])([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66591750tert-Butyl 4-((2-(trifluoromethyl)phenyl)amino)piperidine-1-carboxylate

Product 1

HCID 54902682Piperidin-4-yl-(2-trifluoromethylphenyl)amine

Sources & evidence

ORD record
ord-ecfc92e96720444fa7b8b1412b956bcb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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