Tetrahydrofuran → Bis[(2-methylpropan-2-yl)oxy]phosphoryloxymethyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indole-1-carboxylate

HRID 316391Notes

Reaction equation

HRID 316391 reaction equation
[C:30]([CH3:31])([CH3:32])([CH3:33])[O:34][P:35](=[O:36])([O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[O-:42].[CH2:43]([N+:44]([CH2:45][CH2:46][CH2:47][CH3:48])([CH2:49][CH2:50][CH2:51][CH3:52])[CH2:53][CH2:54][CH2:55][CH3:56])[CH2:57][CH2:58][CH3:59].[I:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[C:7](=[O:29])[C:8]([F:19])([c:20]2[c:21]([O:27][CH3:28])[cH:22][cH:23][c:24]([Cl:26])[cH:25]2)[c:9]2[cH:10][cH:11][c:12]([C:15]([F:16])([F:17])[F:18])[cH:13][c:14]21.[O:60]1[CH2:61][CH2:62][CH2:63][CH2:64]1>>[CH2:2]([O:3][C:4](=[O:5])[N:6]1[C:7](=[O:29])[C:8]([F:19])([c:20]2[c:21]([O:27][CH3:28])[cH:22][cH:23][c:24]([Cl:26])[cH:25]2)[c:9]2[cH:10][cH:11][c:12]([C:15]([F:16])([F:17])[F:18])[cH:13][c:14]21)[O:42][P:35]([O:34][C:30]([CH3:31])([CH3:32])[CH3:33])(=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 4191557Ditert-butyl phosphateHCID 208227933-(5-Chloro-2-methoxy-phenyl)-3-fluoro-2-oxo-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid iodomethyl ester

Product 1

HCID 77640514Bis[(2-methylpropan-2-yl)oxy]phosphoryloxymethyl 3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indole-1-carboxylate

Sources & evidence

ORD record
ord-431d9ef33ca74c0faf84e604c3da328e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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