Sulfuric Acid → 7,8-Dimethoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

HRID 316411Notes

Reaction equation

HRID 316411 reaction equation
[CH3:1][O:2][c:3]1[c:4]([CH2:5][NH:6][CH2:7][CH:8]([c:9]2[cH:10][c:11]([O:17][CH3:18])[c:12]([O:15][CH3:16])[cH:13][cH:14]2)[OH:19])[cH:20][cH:21][cH:22][c:23]1[O:24][CH3:25].[OH:31][C:32]([C:33]([F:34])([F:35])[F:36])=[O:37].[S:26](=[O:27])(=[O:28])([OH:29])[OH:30]>>[CH3:1][O:2][c:3]1[c:4]2[c:20]([cH:21][cH:22][c:23]1[O:24][CH3:25])[CH:8]([c:9]1[cH:10][c:11]([O:17][CH3:18])[c:12]([O:15][CH3:16])[cH:13][cH:14]1)[CH2:7][NH:6][CH2:5]2

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 6422Trifluoroacetic acidHCID 14719553alpha-[[(2,3-Dimethoxybenzyl)amino]methyl]-3,4-dimethoxybenzyl alcohol

Product 1

HCID 147195577,8-Dimethoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Sources & evidence

ORD record
ord-b6130d7c53504b74983220f2cf695d2f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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