Hydrochloric Acid → 7-chloro-6-[[[1-[2-(7-fluoro-2-oxoquinolin-1-yl)ethyl]piperidin-3-yl]methylamino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one

HRID 316517Notes

Reaction equation

HRID 316517 reaction equation
[C:37]([O:38][BH-:39]([O:40][C:41](=[O:42])[CH3:43])[O:44][C:45](=[O:46])[CH3:47])(=[O:48])[CH3:49].[CH3:52][OH:53].[CH3:54][CH2:55][O:56][CH2:57][CH3:58].[Cl:23][c:24]1[cH:25][c:26]2[c:31]([n:32][c:33]1[CH:34]=[O:35])[NH:30][C:29](=[O:36])[CH2:28][O:27]2.[Cl:59][CH2:60][Cl:61].[ClH:51].[NH2:1][CH2:2][CH:3]1[CH2:4][N:5]([CH2:9][CH2:10][n:11]2[c:12](=[O:22])[cH:13][cH:14][c:15]3[cH:16][cH:17][c:18]([F:21])[cH:19][c:20]23)[CH2:6][CH2:7][CH2:8]1.[Na+:50]>>[NH:1]([CH2:2][CH:3]1[CH2:4][N:5]([CH2:9][CH2:10][n:11]2[c:12](=[O:22])[cH:13][cH:14][c:15]3[cH:16][cH:17][c:18]([F:21])[cH:19][c:20]23)[CH2:6][CH2:7][CH2:8]1)[CH2:34][c:33]1[c:24]([Cl:23])[cH:25][c:26]2[c:31]([n:32]1)[NH:30][C:29](=[O:36])[CH2:28][O:27]2

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 2724942TriacetoxyborohydrideHCID 574868727-Chloro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehydeHCID 178510054HCID 178510054, compound

Product 1

HCID 1785168627-chloro-6-[[[1-[2-(7-fluoro-2-oxoquinolin-1-yl)ethyl]piperidin-3-yl]methylamino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one

Sources & evidence

ORD record
ord-4db9704ba4444d57926dbc58907207bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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