Dimethyl Sulfoxide → p-Tolyl 4-(5-chloro-6-fluoropyridin-3-yloxy)-2,5-difluorobenzoate

HRID 316910Notes

Reaction equation

HRID 316910 reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[CH3:35][S:36]([CH3:37])=[O:38].[CH3:39][CH2:40][O:41][C:42]([CH3:43])=[O:44].[Cl:26][c:27]1[cH:28][c:29]([OH:34])[cH:30][n:31][c:32]1[F:33].[F:7][c:8]1[c:9]([C:10](=[O:11])[O:12][c:13]2[cH:14][cH:15][c:16]([CH3:19])[cH:17][cH:18]2)[cH:20][c:21]([F:25])[c:22]([F:24])[cH:23]1.[K+:5].[K+:6]>>[F:7][c:8]1[c:9]([C:10](=[O:11])[O:12][c:13]2[cH:14][cH:15][c:16]([CH3:19])[cH:17][cH:18]2)[cH:20][c:21]([F:25])[c:22]([O:34][c:29]2[cH:28][c:27]([Cl:26])[c:32]([F:33])[n:31][cH:30]2)[cH:23]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 224515553-Chloro-2-fluoro-5-hydroxypyridineHCID 580424084-Methylphenyl 2,4,5-trifluorobenzoate

Product 1

HCID 58042398p-Tolyl 4-(5-chloro-6-fluoropyridin-3-yloxy)-2,5-difluorobenzoate

Sources & evidence

ORD record
ord-1868e46b501c41488ee006d75f9f7c95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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