Formaldehyde → 4-(2-Fluoro-4-nitrophenoxy)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinoline

HRID 317151Notes

Reaction equation

HRID 317151 reaction equation
[C:1]([O:2][C:6](=[O:3])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][c:16]2[c:17]([O:37][CH3:38])[cH:18][c:19]3[c:20]([O:26][c:27]4[c:28]([F:36])[cH:29][c:30]([N+:33](=[O:34])[O-:35])[cH:31][cH:32]4)[cH:21][cH:22][n:23][c:24]3[cH:25]2)[CH2:12][CH2:13]1)([CH3:4])([CH3:5])[CH3:7].[CH2:46]=[O:47].[Cl:48][CH2:49][Cl:50].[F:39][C:40]([F:41])([F:42])[C:43]([OH:44])=[O:45]>>[CH3:6][N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][c:16]2[c:17]([O:37][CH3:38])[cH:18][c:19]3[c:20]([O:26][c:27]4[c:28]([F:36])[cH:29][c:30]([N+:33](=[O:34])[O-:35])[cH:31][cH:32]4)[cH:21][cH:22][n:23][c:24]3[cH:25]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 712FormaldehydeHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59342475tert-Butyl 4-(((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate

Product 1

HCID 596475664-(2-Fluoro-4-nitrophenoxy)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinoline

Sources & evidence

ORD record
ord-2fc42d48bca54e0ba82dff7e14ca8639
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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