HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(((4-((2-methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole → 2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-ethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(((4-((2-methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzimidazole | HCID 12003120 | — |
| Reactant | (4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-ethylpyridin-2-yl)methanol | HCID 59792593 | — |
| Reactant | 2-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776002 | — |
| Product | 2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-ethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66775723 | 25% |
Reaction Steps
The same procedure as in the steps (6d), (6e), and (6f) of Example 6 was repeated using the (4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3-ethylpyridin-2-yl)methanol obtained in the step (92d) above to obtain the title compound (159 mg, overall yield: 25%) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425634B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-4a6396352a734809bd4d706bfd577d65 |
| Source note | uspto-grants-2008_09 |