Hydrogen Bromide → 3-[1-(2-Chloro-6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-quinazoline

HRID 317366Notes

Reaction equation

HRID 317366 reaction equation
[BrH:1].[CH3:2][n:3]1[c:4](=[O:21])[n:5]([CH:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[c:6](=[O:14])[c:7]2[cH:8][c:9]([CH3:13])[cH:10][cH:11][c:12]12.[Cl:22][c:23]1[n:24][c:25]2[cH:26][c:27]([O:36][CH3:37])[c:28]([O:34][CH3:35])[cH:29][c:30]2[c:31]([Cl:33])[n:32]1>>[CH3:2][n:3]1[c:4](=[O:21])[n:5]([CH:15]2[CH2:16][CH2:17][N:18]([c:31]3[c:30]4[c:25]([n:24][c:23]([Cl:22])[n:32]3)[cH:26][c:27]([O:36][CH3:37])[c:28]([O:34][CH3:35])[cH:29]4)[CH2:19][CH2:20]2)[c:6](=[O:14])[c:7]2[cH:8][c:9]([CH3:13])[cH:10][cH:11][c:12]12

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 5203272,4-Dichloro-6,7-dimethoxyquinazolineHCID 218512231,6-Dimethyl-3-piperidin-4-ylquinazoline-2,4-dione

Product 1

HCID 154345133-[1-(2-Chloro-6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-quinazoline

Sources & evidence

ORD record
ord-1d76782272574282bee9ede3ba85aac2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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