Tetrahydrofuran → methyl 5-amino-4-[7-[[3-fluoro-4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate

HRID 317511Notes

Reaction equation

HRID 317511 reaction equation
[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[CH3:31][O:32][C:33]([CH2:34][CH2:35][CH:36]([N:37]1[C:38](=[O:47])[c:39]2[cH:40][cH:41][cH:42][c:43]([OH:46])[c:44]2[CH2:45]1)[C:48]([NH2:49])=[O:50])=[O:51].[F:1][c:2]1[cH:3][c:4]([CH2:15][OH:16])[cH:5][cH:6][c:7]1[CH2:8][N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1.[N:17]([C:18]([O:19][CH:20]([CH3:21])[CH3:22])=[O:23])=[N:24][C:25]([O:26][CH:27]([CH3:28])[CH3:29])=[O:30]>>[F:1][c:2]1[cH:3][c:4]([CH2:15][O:16][c:43]2[cH:42][cH:41][cH:40][c:39]3[c:44]2[CH2:45][N:37]([CH:36]([CH2:35][CH2:34][C:33]([O:32][CH3:31])=[O:51])[C:48]([NH2:49])=[O:50])[C:38]3=[O:47])[cH:5][cH:6][c:7]1[CH2:8][N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 58389139Methyl 5-amino-4-(4-hydroxy-1-oxoisoindolin-2-yl)-5-oxopentanoateHCID 67332617HCID 67332617, compound

Product 1

HCID 67334455methyl 5-amino-4-[7-[[3-fluoro-4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate

Sources & evidence

ORD record
ord-ef5b212aa0324380ae59ca5a215f39c7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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