Methanol → 7-Amino-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline

HRID 317628Notes

Reaction equation

HRID 317628 reaction equation
[CH3:39][OH:40].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[F:8][c:9]1[cH:10][cH:11][c:12]([NH:15][C:16](=[O:17])[N:18]2[CH2:19][CH2:20][N:21]([c:24]3[cH:25][cH:26][n:27][c:28]4[cH:29][c:30]([N+:34]([O-:35])=[O:36])[cH:31][cH:32][c:33]34)[CH2:22][CH2:23]2)[cH:13][cH:14]1.[H:37][H:38]>>[F:8][c:9]1[cH:10][cH:11][c:12]([NH:15][C:16](=[O:17])[N:18]2[CH2:19][CH2:20][N:21]([c:24]3[cH:25][cH:26][n:27][c:28]4[cH:29][c:30]([NH2:34])[cH:31][cH:32][c:33]34)[CH2:22][CH2:23]2)[cH:13][cH:14]1

Participants

5

Reactant 4

HCID 887MethanolHCID 6422Trifluoroacetic acidHCID 21101695N-(4-fluorophenyl)-4-(7-nitroquinolin-4-yl)piperazine-1-carboxamideHCID 178418361HCID 178418361, compound

Product 1

HCID 211017417-Amino-4-[4-(4-fluorophenylaminocarbonyl)piperazin-1-yl]quinoline

Sources & evidence

ORD record
ord-389c4b6a73fe4d83a0690bdb6498be27
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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