Trimethylaluminum → 7-Bromo-3-chloro-8-fluoro-2',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,3'-[1,4]oxazin]-5'-amine
Reaction equation
[CH3:24][Al:25]([CH3:26])[CH3:27].[NH2:1][C:2]1([CH2:19][O:20][CH2:21][C:22]#[N:23])[c:3]2[cH:4][c:5]([Br:18])[c:6]([F:17])[cH:7][c:8]2[O:9][c:10]2[n:11][cH:12][c:13]([Cl:16])[cH:14][c:15]21>>[N:1]1=[C:22]([NH2:23])[CH2:21][O:20][CH2:19][C:2]12[c:3]1[cH:4][c:5]([Br:18])[c:6]([F:17])[cH:7][c:8]1[O:9][c:10]1[n:11][cH:12][c:13]([Cl:16])[cH:14][c:15]12Participants
3
Sources & evidence
- ORD record
- ord-472a0e83eb644ab0b4efb269616307a4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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