Hydrogen Bromide → ethyl 2-amino-5-bromothiazole-4-carboxylate

HRID 317695Notes

Reaction equation

HRID 317695 reaction equation
[Br:12][CH2:13][C:14](=[O:15])[C:16]([O:17][CH2:18][CH3:19])=[O:20].[Br:30].[BrH:37].[NH2:1][c:2]1[s:3][cH:4][c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:6]1.[NH2:21][C:22](=[S:23])[NH2:24].[Na+:31].[Na+:32].[O-:33][C:34](=[O:35])[O-:36].[o:25]1[cH:26][cH:27][n:28][cH:29]1>>[NH2:1][c:2]1[s:3][c:4]([Br:12])[c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[n:6]1

Participants

8

Reactant 7

HCID 260Hydrogen Bromide2×HCID 923Sodium ion2×HCID 9255OxazoleHCID 19660Carbonate IonHCID 66144Ethyl bromopyruvateHCID 73216Ethyl 2-aminothiazole-4-carboxylateHCID 2723790Thiourea

Product 1

HCID 1284665ethyl 2-amino-5-bromothiazole-4-carboxylate

Sources & evidence

ORD record
ord-130517681cea45518ad2478ac4b3ccc0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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