Tetrahydrofuran → Tert-butyl 4-(5-(2-fluoronicotinoyl)thiazol-2-yl)-1,4-diazepane-1-carboxylate

HRID 317804Notes

Reaction equation

HRID 317804 reaction equation
[C:6]([CH3:7])([CH3:8])([CH3:9])[O:10][C:11](=[O:12])[N:13]1[CH2:14][CH2:15][N:16]([c:20]2[s:21][cH:22][cH:23][n:24]2)[CH2:17][CH2:18][CH2:19]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[F:25][c:26]1[c:27]([C:28](=[O:29])[N:30]([O:31][CH3:32])[CH3:33])[cH:34][cH:35][cH:36][n:37]1.[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1>>[C:6]([CH3:7])([CH3:8])([CH3:9])[O:10][C:11](=[O:12])[N:13]1[CH2:14][CH2:15][N:16]([c:20]2[s:21][c:22]([C:28]([c:27]3[c:26]([F:25])[n:37][cH:36][cH:35][cH:34]3)=[O:29])[cH:23][n:24]2)[CH2:17][CH2:18][CH2:19]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 534170672-Fluoro-N-methoxy-N-methylnicotinamideHCID 57690677Tert-butyl 4-(thiazol-2-yl)-1,4-diazepane-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 57690516Tert-butyl 4-(5-(2-fluoronicotinoyl)thiazol-2-yl)-1,4-diazepane-1-carboxylate

Sources & evidence

ORD record
ord-1054012d8ebe4ffbb80b8a1f19117dbd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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