Dimethylformamide dimethyl acetal → 2-Benzotriazolyl-1-(2,4-dichlorophenyl)-3-(dimethylamino)prop-2-en-1-one

HRID 31785Notes

Reaction equation

HRID 31785 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([CH2:10][C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[O:12])[C:4]=2[N:3]=[N:2]1.CO[CH:23](OC)[N:24]([CH3:26])[CH3:25]>>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10](=[CH:23][N:24]([CH3:26])[CH3:25])[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[O:12])[C:4]=2[N:3]=[N:2]1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178520204HCID 178520204, compound

Product 1

HCID 1784835732-Benzotriazolyl-1-(2,4-dichlorophenyl)-3-(dimethylamino)prop-2-en-1-one

Procedure

2-benzotriazolyl-1-(2,4-dichlorophenyl)ethan-1-one was dissolved in dimethyl-formamide dimethyl acetal (5 mL) and the solution refluxed for 8 h. Evaporation of the solvent gave 2-benzotriazolyl-1-(2,4-dichlorophenyl)-3-(dimethylamino)prop-2-en-1-one as an air sensitive red solid which was used in the next step without further purification.

Workup

  1. temperaturethe solution refluxed for 8 h
  2. customEvaporation of the solvent

Sources & evidence

ORD record
ord-4ce825cb359b44c996f500b4a1570dcd
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Reaction notes

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