Tetrahydrofuran → 2-[4-(2,2-dimethylbutyl)-1-trityl-1H-imidazol-2-yl]-1-[4-(5-fluoropyridin-2-yl)phenyl]ethanone
Reaction equation
[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:6][C:7]([CH2:8][c:9]1[n:10][c:11]([CH3:33])[n:12]([C:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)([c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:13]1)([CH2:34][CH3:35])[CH3:36].[F:37][c:38]1[cH:39][cH:40][c:41](-[c:44]2[cH:45][cH:46][c:47]([C:48](=[O:49])[N:50]([O:51][CH3:52])[CH3:53])[cH:54][cH:55]2)[n:42][cH:43]1.[O:56]1[CH2:57][CH2:58][CH2:59][CH2:60]1>>[CH3:6][C:7]([CH2:8][c:9]1[n:10][c:11]([CH2:33][C:48]([c:47]2[cH:46][cH:45][c:44](-[c:41]3[cH:40][cH:39][c:38]([F:37])[cH:43][n:42]3)[cH:55][cH:54]2)=[O:49])[n:12]([C:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)([c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[cH:13]1)([CH2:34][CH3:35])[CH3:36]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-bdc762b945f04a238da4e52927fc2de9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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