Hydrochloric Acid → 3-[3-oxo-7-[[4-(piperazin-1-ylmethyl)phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione

HRID 318617Notes

Reaction equation

HRID 318617 reaction equation
[CH2:48]1[O:49][CH2:50][CH2:51][O:52][CH2:53]1.[Cl:54][CH2:55][Cl:56].[ClH:41].[O:1]=[C:2]1[NH:3][C:4](=[O:40])[CH2:5][CH2:6][CH:7]1[N:8]1[C:9](=[O:39])[c:10]2[cH:11][cH:12][cH:13][c:14]([O:17][CH2:18][c:19]3[cH:20][cH:21][c:22]([CH2:23][N:24]4[CH2:25][CH2:26][N:27]([C:30]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:36])[CH2:28][CH2:29]4)[cH:37][cH:38]3)[c:15]2[CH2:16]1.[O:42]1[CH2:43][CH2:44][O:45][CH2:46][CH2:47]1>>[O:1]=[C:2]1[NH:3][C:4](=[O:40])[CH2:5][CH2:6][CH:7]1[N:8]1[C:9](=[O:39])[c:10]2[cH:11][cH:12][cH:13][c:14]([O:17][CH2:18][c:19]3[cH:20][cH:21][c:22]([CH2:23][N:24]4[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]4)[cH:37][cH:38]3)[c:15]2[CH2:16]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 312751,4-Dioxane2×HCID 53353411tert-butyl 4-[[4-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]methyl]piperazine-1-carboxylate

Product 1

HCID 673335653-[3-oxo-7-[[4-(piperazin-1-ylmethyl)phenyl]methoxy]-1H-isoindol-2-yl]piperidine-2,6-dione

Sources & evidence

ORD record
ord-9d2478d52c114e75987a39b1055b2286
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…