Benzenesulfonyl chloride → 2-chloro-5-methoxy-1H-indole

HRID 319789Notes

Reaction equation

HRID 319789 reaction equation
[CH2:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1.[CH2:54]1[O:55][CH2:56][CH2:57][CH2:58]1.[CH3:1][O:2][C:3](=[O:4])[CH2:17][c:5]1[c:6]([Cl:16])[nH:7][c:8]2[cH:9][cH:10][c:11]([O:14][CH3:15])[cH:12][c:13]12.[CH3:29][N:30]([CH2:31][n:32]1[c:33]2[c:34]([cH:35][c:36]([O:37][CH3:38])[cH:39][cH:40]2)[cH:41][cH:42]1)[CH3:43].[CH:24]([Li:25])([CH2:26][CH3:27])[CH3:28].[c:44]1([S:45]([Cl:46])(=[O:47])=[O:48])[cH:49][cH:50][cH:51][cH:52][cH:53]1>>[cH:5]1[c:6]([Cl:16])[nH:7][c:8]2[cH:9][cH:10][c:11]([O:14][CH3:15])[cH:12][c:13]12

Participants

7

Reactant 6

HCID 7369Benzenesulfonyl chlorideHCID 8028TetrahydrofuranHCID 8078CyclohexaneHCID 10608272HCID 10608272, compoundHCID 10824783HCID 10824783, compoundHCID 178418400CID 53628100

Product 1

HCID 105835622-chloro-5-methoxy-1H-indole

Sources & evidence

ORD record
ord-29213f62513e419b9717aaf264683e4b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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