1-Amino-2-propanol → 4-[[5-(1-Aminopropan-2-yloxy)quinazolin-4-yl]amino]-2-chlorophenol

HRID 320646Notes

Reaction equation

HRID 320646 reaction equation
[Cl:26][c:27]1[cH:28][c:29]([NH:30][c:31]2[c:32]3[c:33]([cH:34][cH:35][cH:36][c:37]3[O:38][CH2:39][CH2:40][NH:41][CH3:42])[n:43][cH:44][n:45]2)[cH:46][cH:47][c:48]1[O:49][CH2:50][c:51]1[cH:52][cH:53][cH:54][cH:55][n:56]1.[Cl:6][c:7]1[c:8]([OH:25])[cH:9][cH:10][c:11]([NH:13][c:14]2[n:15][cH:16][n:17][c:18]3[cH:19][cH:20][cH:21][c:22]([F:24])[c:23]23)[cH:12]1.[NH2:1][CH2:2][CH:3]([CH3:4])[OH:5]>>[NH2:1][CH2:2][CH:3]([CH3:4])[O:5][c:22]1[cH:21][cH:20][cH:19][c:18]2[n:17][cH:16][n:15][c:14]([NH:13][c:11]3[cH:10][cH:9][c:8]([OH:25])[c:7]([Cl:6])[cH:12]3)[c:23]21

Participants

4

Reactant 3

HCID 41-Amino-2-propanolHCID 574449782-Chloro-4-[(5-fluoroquinazolin-4-yl)amino]phenolHCID 69065361N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-[2-(methylamino)ethoxy]quinazolin-4-amine

Product 1

HCID 765497974-[[5-(1-Aminopropan-2-yloxy)quinazolin-4-yl]amino]-2-chlorophenol

Sources & evidence

ORD record
ord-5f34ffaf7e6347598a40dc28cf966d7e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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