Pyridine → N-isoxazol-5-yl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide
Reaction equation
[CH2:44]([Cl:45])[Cl:46].[CH3:1][c:2]1[c:3](-[n:11]2[cH:12][n:13][c:14]3[cH:15][cH:16][c:17]([N:22]4[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]4)[cH:18][c:19]3[c:20]2=[O:21])[cH:4][c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1.[NH2:38][c:39]1[cH:40][cH:41][n:42][o:43]1.[O:29]=[CH:30][N:31]([CH3:32])[CH3:33].[S:34]([Cl:35])([Cl:36])=[O:37].[cH:47]1[cH:48][cH:49][n:50][cH:51][cH:52]1>>[CH3:1][c:2]1[c:3](-[n:11]2[cH:12][n:13][c:14]3[cH:15][cH:16][c:17]([N:22]4[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]4)[cH:18][c:19]3[c:20]2=[O:21])[cH:4][c:5]([C:6](=[O:8])[NH:38][c:39]2[cH:40][cH:41][n:42][o:43]2)[cH:9][cH:10]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-fa559eb7e801451cb2b3c0f2707aa3d8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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