反应详情

6-Piperidin-1-ylmethyl-1,2,3,4-tetrahydro-naphthalen-2-ylamine bis-TFA salt (Step F) (0.143 g, 0.327 mmol), 3-(naphthalen-2-yl-sulfonylamino)-3-phenyl-propionic acid (0.128 g, 0.360 mmol), HOBt (0.057 g, 0.425 mmol) and EDC (0.081 g, 0.425 mmol) were dissolved in CH2Cl2 (25 mL) and stirred at RT. TEA (0.228 mL, 1.64 mmol) was added drop-wise to the mixture and the reaction was stirred at RT until HPLC analysis showed complete consumption of starting material. The reaction mixture was diluted with CH2Cl2 and washed with saturated aqueous NaHCO3. The organic layer was dried over MgSO4 and concentrated in vacuo to afford the crude material. The crude was purified by flash column chromatography to furnish the title compound. MS (APCI pos) 582 (M+H).

1. stirringthe reaction was stirred at RT until HPLC analysis
2. customconsumption of starting material
3. additionThe reaction mixture was diluted with CH2Cl2
4. washwashed with saturated aqueous NaHCO3
5. dry with materialThe organic layer was dried over MgSO4
6. concentrationconcentrated in vacuo
7. customto afford the crude material
8. customThe crude was purified by flash column chromatography