反应详情

To a solution of N-[6-(2-Cyano-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-3-(3,4-dichloro-benzenesulfonylamino)-3-(4-fluoro-phenyl)-propionamide (150 mg, 0.26 mmol) in EtOH:CHCl3 mixture (75:25, 10 mL) was added PtO2 (18 mg, 0.078 mmol). The resulting mixture was flushed under N2 gas followed by evacuating—this was done 3 times. After last evacuation, the hydrogen balloon was inserted. The reaction mixture was stirred under H2 at RT for 2 h. Solvent was separated from the PtO2 by passing through the Celite®. Solvent was evaporated in vacuo to give the final product. MS m/z: 579.11 (M+H). Calc'd. for C28H30Cl2FN3O3S-578.53.

1. customThe resulting mixture was flushed under N2 gas
2. customby evacuating—this
3. customSolvent was separated from the PtO2
4. customSolvent was evaporated in vacuo