反应详情

温度

0 °C

To a flask charged with N-[6-(1-hydroxymethyl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-3-phenyl-3-(3-trifluoromethyl-benzenesulfonylamino)-propionamide (Step F, 558 mg, 1.0 mmol, 1.0 eq) was added CH2Cl2 (7 mL) and Et3N (0.18 mL, 1.3 mmol, 1.3 eq). The suspension was cooled to 0° C., purged with N2, and then added the CH2Cl2 solution (1 mL) of methanesulfonyl chloride (Aldrich, 0.1 mL, 1.3 mmol, 1.3 eq). The mixture was concentrated in vacuo after 1 h. The crude was dried on vacuum and used for next step directly.

1. custompurged with N2
2. concentrationThe mixture was concentrated in vacuo after 1 h
3. customThe crude was dried on vacuum