Hydrochloric Acid → [5-(1H-Pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

HRID 321288Notes

Reaction equation

HRID 321288 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[n:8]1[n:9][cH:10][c:11](-[c:13]2[cH:14][cH:15][cH:16][c:17]3[n:18]2[n:19][c:20]([NH:22][c:23]2[cH:24][cH:25][c:26]([O:29][CH2:30][CH2:31][N:32]4[CH2:33][CH2:34][CH2:35][CH2:36]4)[cH:27][cH:28]2)[n:21]3)[cH:12]1.[CH3:40][OH:41].[ClH:37].[H:38][H:39].[OH-:42].[OH-:44].[Pd+2:43]>>[n:8]1[nH:9][cH:10][c:11](-[c:13]2[cH:14][cH:15][cH:16][c:17]3[n:18]2[n:19][c:20]([NH:22][c:23]2[cH:24][cH:25][c:26]([O:29][CH2:30][CH2:31][N:32]4[CH2:33][CH2:34][CH2:35][CH2:36]4)[cH:27][cH:28]2)[n:21]3)[cH:12]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 59590042[5-(1-Benzyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amineHCID 178418361HCID 178418361, compound

Product 1

HCID 136146545[5-(1H-Pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Sources & evidence

ORD record
ord-377a1c5b64c941459b71a6802c9d1ec5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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