Chloromethyl Methyl Ether → Tert-butyl 2,4-dimethoxybenzyl(methoxymethyl)carbamate

HRID 321587Notes

Reaction equation

HRID 321587 reaction equation
[CH2:20]([Li:21])[CH2:22][CH2:23][CH3:24].[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:1][O:2][c:3]1[c:4]([CH2:5][NH:6][C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[cH:14][cH:15][c:16]([O:18][CH3:19])[cH:17]1.[Cl:25][CH2:26][O:27][CH3:28]>>[CH3:1][O:2][c:3]1[c:4]([CH2:5][N:6]([C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[CH2:26][O:27][CH3:28])[cH:14][cH:15][c:16]([O:18][CH3:19])[cH:17]1

Participants

5

Reactant 4

HCID 7864Chloromethyl Methyl EtherHCID 8028TetrahydrofuranHCID 63788699tert-butyl N-[(2,4-dimethoxyphenyl)methyl]carbamateHCID 178418339Butyllithium

Product 1

HCID 66618166Tert-butyl 2,4-dimethoxybenzyl(methoxymethyl)carbamate

Sources & evidence

ORD record
ord-75451c1037e149aab01c10103ce2f965
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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