5-Amino-2-methoxyphenol → 1,3-Dichloro-2,4,6-trifluoro-5-[(3-hydroxy-4-methoxyphenyl)aminosulfonyl]benzene

HRID 321925Notes

Reaction equation

HRID 321925 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[NH2:5].[Cl:11][C:12]1[C:13]([F:25])=[C:14]([S:21](Cl)(=[O:23])=[O:22])[C:15]([F:20])=[C:16]([Cl:19])[C:17]=1[F:18]>>[Cl:11][C:12]1[C:13]([F:25])=[C:14]([S:21]([NH:5][C:4]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:2]([OH:1])[CH:3]=2)(=[O:23])=[O:22])[C:15]([F:20])=[C:16]([Cl:19])[C:17]=1[F:18]

Participants

3

Reactant 2

HCID 743145-Amino-2-methoxyphenolHCID 155506413,5-Dichloro-2,4,6-trifluorophenylsulfonyl chloride

Product 1

HCID 98658171,3-Dichloro-2,4,6-trifluoro-5-[(3-hydroxy-4-methoxyphenyl)aminosulfonyl]benzene

Procedure

The title compound was prepared in a manner similar to that described in Example 6 of WO 97/3-677, beginning with 3-hydroxy4-methoxyaniline and 3,5-dichloro-2,4,6-trifluorophenylsulfonyl chloride (Example A, above).

Sources & evidence

ORD record
ord-38f57edbfcc04f3d925488c3b71ab347
Source dataset
uspto-grants-2001_04
Patent number
US06211167B1

Reaction notes

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