反应详情

Ethanol (8 ml) and 10% sodium hydroxide aqueous solution (3.7 g) are added to 2-benzyl-1-(2-chlorobenzyl)-5-ethoxycarbonylbenzimidazole (0.635 g) (example 16), and the solution is refluxed for 4 hours. After the reaction solution is cooled, its acidity is adjusted to pH 6 with 10% hydrochloric acid. The sediment is gathered, washed with water, dried under reduced pressure, and thus, 2-benzyl-5-carboxy-1-(2-chlorobenzyl) benzimidazole (143) (0.488 g) is obtained.

1. temperaturethe solution is refluxed for 4 hours
2. temperatureAfter the reaction solution is cooled
3. washwashed with water
4. customdried under reduced pressure