反应详情

A solution of 2-bromo-6-chlorobenzoic acid chloride (0.5 mmol) in dichloromethane (5 ml) was added dropwise to a solution of 2,3-dihydro-4-pyridinone (5.1 mmol, 495 mg) and triethylamine (1.2 ml) in dichloromethane (20 ml). After stirring for 30 minutes, the solution was diluted with water, separated, the aqueous extract further extracted with dichloromethane, the combined organic extracts combined and washed with brine, dried over sodium sulphate and evaporated. The residue was purified by flash column chromatography on silica eluting with 30% ethyl acetate in hexane to yield the title compound as a pale yellow oil (629 mg). MS (+CI) m/z 316 [M+H]+.

1. customseparated
2. extractionthe aqueous extract further
3. extractionextracted with dichloromethane
4. washwashed with brine
5. dry with materialdried over sodium sulphate
6. customevaporated
7. customThe residue was purified by flash column chromatography on silica eluting with 30% ethyl acetate in hexane