HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322007Generated: October 26, 2026
Thionyl Chloride → 4-(Trifluoromethyl)cinnamoyl chloride
https://huagongshe.com/reaction/322007
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Trifluoromethyl)cinnamic acid | HCID 688070 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-(Trifluoromethyl)cinnamoyl chloride | HCID 11107291 | — |
Reaction Steps
200.0 mg (0.92 mmol) of trans-4-trifluoromethylcinnamic acid were treated with 200 μl of thionyl chloride. After addition of 2 drops of DMF, the reaction solution obtained was stirred at 75° C. for 3 h. It was then concentrated to dryness, and the residue was taken up in toluene 2× and concentrated to dryness again. Drying in a high vacuum yielded 237.0 mg of the title compound as a slightly yellow, amorphous powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06211196B1 |
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| Source dataset | uspto-grants-2001_04 |
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| ORD ID | ord-fc6c1c230be84f99a7c445e3d7914d02 |
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| Source note | uspto-grants-2001_04 |
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