反应详情

温度

100 °C

200 g (1.24 mol) of 2,6-dichlorotoluene were dissolved in 600 ml of hexamethylphosphoramide and treated with 130.41 g (1.86 mol) of sodium thiomethoxide. The mixture was then heated at 100° C. for 3 h. It was allowed to cool, 88.2 g (0.5 mol) of iodomethane were added and it was stirred at room temperature for 0.5 h. The mixture was then added to 3.5 l of water and extracted with ethyl acetate. The combined organic phases were washed with water, dried over MgSO4 and completely concentrated on a rotary evaporator.

1. temperatureto cool
2. extractionextracted with ethyl acetate
3. washThe combined organic phases were washed with water
4. dry with materialdried over MgSO4
5. concentrationcompletely concentrated on a rotary evaporator