Sodium Hydroxide → HCID 9869065, compound

HRID 322084Notes

Reaction equation

HRID 322084 reaction equation
C([O:3][C:4](=[O:36])[CH2:5][C@@H:6]([C:27]1[CH:35]=[CH:34][C:30]2[CH2:31][CH2:32][O:33][C:29]=2[CH:28]=1)[N:7]1[CH2:12][CH2:11][CH2:10][N:9]([CH2:13][CH2:14][CH2:15][C:16]2[CH:25]=[CH:24][C:23]3[CH2:22][CH2:21][CH2:20][NH:19][C:18]=3[N:17]=2)[C:8]1=[O:26])C.[OH-].[Na+]>CCO>[O:33]1[C:29]2[CH:28]=[C:27]([C@@H:6]([N:7]3[CH2:12][CH2:11][CH2:10][N:9]([CH2:13][CH2:14][CH2:15][C:16]4[CH:25]=[CH:24][C:23]5[CH2:22][CH2:21][CH2:20][NH:19][C:18]=5[N:17]=4)[C:8]3=[O:26])[CH2:5][C:4]([OH:36])=[O:3])[CH:35]=[CH:34][C:30]=2[CH2:31][CH2:32]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15521930HCID 15521930, compound

Product 1

HCID 9869065HCID 9869065, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-12 (0.20 g, 0.41 mmol) in EtOH (5 mL) was added 1N NaOH (0.5 ml, 0.5 mmol). After stirring for 2 h, the solvents were evaporated and the residue was chromatographed (silica gel, 25:10:1:1 followed by 15:10:1:1 ethyl acetate/EtOH/water/NH4OH) to give 4-13 as a white solid.

Workup

  1. customthe solvents were evaporated
  2. customthe residue was chromatographed (silica gel, 25:10:1:1 followed by 15:10:1:1 ethyl acetate/EtOH/water/NH4OH)

Sources & evidence

ORD record
ord-f2c42c72a6d14067b061bdc5326f5ec9
Source dataset
uspto-grants-2001_04
Patent number
US06211191B1

Reaction notes

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