Methyl Isocyanate → HCID 44358238, compound

HRID 322105Notes

Reaction equation

HRID 322105 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([N:10]3[CH2:14][CH2:13][C@@H:12]([NH2:15])[CH2:11]3)[C:4]=2[CH2:3][CH2:2]1.[CH3:16][N:17]=[C:18]=[O:19]>C(Cl)Cl>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([N:10]3[CH2:14][CH2:13][C@@H:12]([NH:15][C:18]([NH:17][CH3:16])=[O:19])[CH2:11]3)[C:4]=2[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 69830104HCID 69830104, compound

Product 1

HCID 44358238HCID 44358238, compoundYield 497.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(R)-N-(2,3-Dihydrobenzofuran-4-yl)-3-(amino)pyrrolidine (0.1 mmol) was dissolved in CH2Cl2 and methyl isocyanate (0.12 mmol) was added. The reaction was stirred at room temperature for 1 hour. The solvents were removed in vacuo, and the compound purified by flash chromatography eluting with 10% methanol in ethyl acetate to give 130 mg (98%) of the desired product as a solid.

Workup

  1. customThe solvents were removed in vacuo
  2. customthe compound purified by flash chromatography
  3. washeluting with 10% methanol in ethyl acetate

Sources & evidence

ORD record
ord-99fe8ae6ec3a469fb7c583547b09d786
Source dataset
uspto-grants-2001_04
Patent number
US06211225B1

Reaction notes

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