Chlorosuccinimide → HCID 69829876, compound

HRID 322107Notes

Reaction equation

HRID 322107 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[C:10]=1[N:11]1[CH2:15][CH2:14][C@H:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:12]1.O1C2C=CC=C(N3CC[C@H](N)C3)C=2CC1.[Cl:35]N1C(=O)CCC1=O>>[Cl:1][C:2]1[CH:3]=[C:4]([Cl:35])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[C:10]=1[N:11]1[CH2:15][CH2:14][C@H:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:12]1

Participants

4

Reactant 3

HCID 31398ChlorosuccinimideHCID 69829806HCID 69829806, compoundHCID 69830457HCID 69830457, compound

Product 1

HCID 69829876HCID 69829876, compound

Procedure

The crude product isolated in Example 34 from the reaction of (S)-N-(2,3-dihydrobenzofuran-4-yl)-3-(amino)pyrrolidine (0.1 mmol) and N-chlorosuccinimide (0.11 mmol) was purified by preparative HPLC and the minor product of the reaction was isolated to yield the title compound.

Workup

  1. customwas purified by preparative HPLC
  2. customthe minor product of the reaction was isolated

Sources & evidence

ORD record
ord-616a2ca276b54c16a9db11957d2892e3
Source dataset
uspto-grants-2001_04
Patent number
US06211225B1

Reaction notes

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