Hydracrylonitrile → HCID 23004059, compound

HRID 322135Notes

Reaction equation

HRID 322135 reaction equation
C[C:2]1([CH3:18])[O:7][C:6](=[O:8])[CH:5]([C:9](=O)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]C)[C:4](=[O:17])O1.OCC[C:22]#[N:23]>C1(C)C=CC=CC=1>[O:17]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH:5]([C:6]([O:7][CH2:2][CH2:18][C:22]#[N:23])=[O:8])[CH2:4]1

Participants

4

Reactant 2

HCID 8011HydracrylonitrileHCID 12425344HCID 12425344, compound

Product 1

HCID 23004059HCID 23004059, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2,2-dimethyl-5-(1-oxoheptyl)-1,3-dioxane-4,6-dione (29.4 mmol) and 3-hydroxypropionitrile (4.48 g, 63.0 mmol) in 25 mL of dry toluene were heated at reflux temperature for 1 hour. The solvent was removed in vacuo, and the residue was chromatographed on silica gel to give the title compound as a viscous oil, which was used in the next step after spectral characterization.

Workup

  1. temperaturewere heated
  2. temperatureat reflux temperature for 1 hour
  3. customThe solvent was removed in vacuo
  4. customthe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-ebfb95e0a3eb4d04a87033329ba1c0e8
Source dataset
uspto-grants-2001_04
Patent number
US06211198B1

Reaction notes

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