Hydrochloric Acid → HCID 22010045, compound

HRID 322233Notes

Reaction equation

HRID 322233 reaction equation
Cl.C([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][O:14][C:13]3[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:12]=3[C:11](=[O:22])[C:10]=2[CH:23]=1)(=O)C>CO>[NH2:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][O:14][C:13]3[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:12]=3[C:11](=[O:22])[C:10]=2[CH:23]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22010021HCID 22010021, compound

Product 1

HCID 22010045HCID 22010045, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a mixed solvent of concentrated hydrochloric acid (15 ml) and methanol (15 ml), 9-acetamido-2-methoxy-6,11-dihydrodibenz[b,e]oxepin-11-one obtained in Reference Example 10 (0.93 g, 3.1 mmol) was heated under reflux for one hour. After the reaction was completed, substantially the same procedure as in Reference Example 5 was repeated to give 9-amino-2-methoxy-6,11-dihydrodibenz[b,e]oxepin-11-one (yield: 74%).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for one hour

Sources & evidence

ORD record
ord-8bdb4437101347009b2143c431181bed
Source dataset
uspto-grants-2001_04
Patent number
US06211227B1

Reaction notes

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