Benzeneacetamide → 2-Benzyl-4-(chloromethyl)-1,3-oxazole

HRID 322259Notes

Reaction equation

HRID 322259 reaction equation
[C:1]1([CH2:7][C:8]([NH2:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:11][CH2:12][C:13]([CH2:15]Cl)=O>>[CH2:7]([C:8]1[O:9][CH:15]=[C:13]([CH2:12][Cl:11])[N:10]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7680BenzeneacetamideHCID 107931,3-Dichloroacetone

Product 1

HCID 220096022-Benzyl-4-(chloromethyl)-1,3-oxazoleYield 33%

Procedure

In substantially the same manner as in Reference Example 31, phenylacetamide was allowed to react with 1,3-dichloroacetone to give 2-benzyl-4-chloromethyl oxazole. The yield was 33%. Recrystallization from hexane gave colorless prisms, mp 31-32° C.

Sources & evidence

ORD record
ord-e2433385d9a54ad9a35d07a239e0d90d
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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