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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322264Generated: October 25, 2026

1,3-Dichloroacetone → 4-Chloromethyl-2-(3,5-dimethoxyphenyl)oxazole

https://huagongshe.com/reaction/322264

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DichloroacetoneHCID 10793—
Reactant3,5-DimethoxybenzamideHCID 72878—
Product4-Chloromethyl-2-(3,5-dimethoxyphenyl)oxazoleHCID 2200972859%

Reaction Steps

In substantially the same manner as in Reference Example 31, 3,5-dimethoxybenzamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3,5-dimethoxyphenyl)oxazole. The yield was 59%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 85-86° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-1e068f773ee24b4ebacd0233d74729f9
Source noteuspto-grants-2001_04